Research

Research Interests:
  • Nutritional Assessment
  • Body Composition
  • Energy Metabolism
  • Sarcopenic Obesity, Sarcopenia, Obesity, Cachexia
  • Clinical Nutrition
  • Cancer
  • Aging

    Dr. Prado is interested in the study of nutritional assessment and status and most of her research has focused on investigating the prevalence of abnormal body composition (specially sarcopenic obesity) and its relationship to health outcomes in different cohorts of patients. Her research has shown for the first time the prevalence and clinical implications of sarcopenic obesity in cancer, and has provided evidence of the independent effect of body composition on cancer recurrence, treatment and survival. Her expertise also includes the assessment of whole-body macronutrient metabolism and the regulation of body weight and composition during weight loss. Her lab is dedicated to the study of nutrient intake, energy metabolism and skeletal muscle and adipose tissue dynamics and its effect on health. Her lab is particularly interested in studying the relationship between muscle loss, obesity and interacting body composition changes among different susceptible groups.


http://scholar.google.ca/citations?user=mN-tqoAAAAAJ&hl=en


Book Chapters:

Upcoming:

Prado CM, Pinto CL, Gonzalez CM. Heymsfield S. Techniques for Assessment of Body Composition in Health. Scientific American Nutrition Edited by: Robinson ML, Mogensen KM, Saltzman E. SA Nutrition.

Gonzalez CM, Purcell S, Prado CM, Heymsfield S. Body Composition in Starvation and Disease. Scientific American Nutritio Edited by: Robinson ML, Mogensen KM, Saltzman E. SA Nutrition. 

Prado CM, Elliott SA, Mota JF. Nutritional status and assessment with advanced imaging techniques. Eds. Hickson M, Smith S. In: Advanced Nutrition & Dietetics in Nutrition Support, British Dietetic Association. Accepted: Publication expected for 2016.

Gonzalez MC, Prado CM, Barbosa-Silva TG, Belarmino G, Pereira A, Horie LM, Hoffman DJ, Heymsfield SB, Waitzberg DL. Composição Corporal (Body Composition). Chapter 19. In: Nutrição Oral, Enteral e Parenteral - 5ed. Ed. Dan K Waitzberg. Book in Portuguese.

Published:

Siervo M, Prado CM. Nutritional assessment of the critically ill patient. In: Nutrition in Critical Care, P Faber, M Siervo Editors, Cambridge University Press, Cambridge UK, 2014, p. 13-20.

Baracos VE, Prado CM, Antoun S, Gioulbasanis I. Assessement of nutritional status. In: Nutrition and the Cancer Patient, E Del Fabbro, V Baracos, W Demark-Wahnefried, T Bowling, J Hopkinson, E Bruera Editors, Oxford University Press, Oxford UK, 2010, p. 19-36.



Peer-Reviewed Publications:

Pinto CL, Schirrmacher R, Mattingly S, Sawyer M, Fine EJ, Prado CM. A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review. Accepted: Journal of the Academy of Nutrition and Dietetics. 

Terada T, Boulé NG, Forhan M, Prado CM, Kenny GP, Prud’homme D, Ito E, Sigal RJ. Effects of high fat and low muscle mass on cardiometabolic risks in type 2 diabetes. Accepted: Obesity. 

Kroenke CH, Caan BJ, Prado CM. The optimal body mass index range for patients with colorectal cancer – Reply. JAMA Oncology. Published online December 22, 2016. doi:10.1001/jamaoncol.2016.5280.

Corinna G, Prado CM, Muller M. Inadequacy of body weight-based recommendations for individual protein and energy intake: lessons from body composition analysis. Nutrients 2016 Dec 31;9(1). pii: E23. doi: 10.3390/nu9010023. 

Orsso CE, Mackenzie M, Alberga A , Sharma AM, Richer L, Prado CM, Haqq AM. The use of magnetic resonance imaging to characterize abnormal body composition phenotypes in youth with Prader-Willi syndrome. Accepted: Metabolism, Clinical and Experimental.

Xiao J, Mazurak VC, Olobatuyi TA, Caan BJ, Prado CM. Visceral Adiposity and Cancer Survival: A Review of Imaging Studies. European Journal of Cancer Care. 2016 Dec 6. doi: 10.1111/ecc.12611. [Epub ahead of print] 

Powell M, Lara J, Mocciaro G, Prado CM, Battezzati A, Leone A, Tagliabue A, De Amicis R, Vignati L, Bertoli S, Siervo M. Association between ratio indexes of body composition phenotypes and metabolic risk in Italian adults. Clinical Obesity. Published online on; 21 November 2016. DOI: 10.1111/cob.12165 

Vishal D, Xiao J, Prado CM, Silva AC, Burroughs P, McGee D, Hurt JE, Mohamed SG, Noel T. Batchelor W. CT-derived skeletal muscle index: a novel predictor of frailty and hospital lenght of stat after transcatheter aortic valve replacement. Ahead of print: The American Heart Journal. 

Cespedes Feliciano EM, Kroenke CH, Meyerhadt JA, Prado CM, Bradshaw PT, Dannenberg AJ, Kwan ML, Xiao K, Quesenbery C, Weltzien E, Castillo A, Caan BJ. Metabolic Phenotypes and Mortality among Early Stage Colorectal Cancer Patients. Ahead of print: Journal of Clinical Oncology. 

Carneiro IP, Mazurak VC, Prado CM. Clinical implication of sarcopenic obesity in cancer. Current Oncology Report, 2016. v.18(10): 1-13. 

Johnson Stoklossa C, Forhan M, Padwal RS, Gonzalez MC, Prado CM. Practical considerations for body composition assessment of adults with class II/III obesity using bioelectrical impedance analysis or dual-energy X-ray absorptiometry. Current Obesity Reports. 2016, Volume 5, Issue 4, pp 389–396. 

Cespedes EM, Bradshaw PT, Kroenke CH, Chen WY, Prado CM, Weltzien EK, Castillo AL, Caan BJ. Post-diagnosis Weight Change and Survival Following a Diagnosis of Early Stage Breast Cancer. Ahead of print: Cancer Epidemiology, Biomarkers and Prevention. 2016 Aug 26. pii: cebp.0150.2016. 

Crawford J, Prado CM*, Johnston MA, Gralla RJ, Taylor RP, Hancock ML, Dalton, JT. Study Design and Rationale for the Phase 3 Clinical Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials). * Co-first Author. Current Oncology Reports: 2016 Jun;18(6):37. 

Meyerhardt J, Kroenke CH, Prado CM, Kwan M, Castillo A, Weltzien E, Xiao J, Caan BJ. Association of Weight Change after Colorectal Cancer Diagnosis and Outcomes in the Kaiser Permanente Northern California Population. Accepted: Cancer Epidemiology, Biomarkers and Prevention. 

Kroenke CH, Neugebauer R, Meyerhardt J, Prado CM, Weltzien E, Kwan M, Xiao J, Caan BJ. Analysis of Body Mass Index and Mortality in Patients with Colorectal Cancer Using Causal Diagrams. JAMA Oncology. 2016 Sep 1;2(9):1137-45. doi:10.1001/jamaoncol.2016.0732. Accompaning editorial available. 

Purcell S, Elliott S, Baracos VE, Prado CM. Key Determinants of Energy Expenditure in Cancer and Implications for Clinical Practice. European Journal of Clinical Nutrition 2016,;70(11):1230-1238.

Carneiro IP, Elliott SA, Siervo M, Padwal R, Bertoli S, Battezzati A. Prado CM. Is obesity associated with altered energy expenditure? Advances in Nutrition, 2016 v.7:476-487. 

Cushen SJ, Power DG, Murphy KP, McDermott R, Griffin BT, Lim M, Daly L, Maceneaney P, O'Sullivan K, Prado CM, Ryan AM. Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel. Clinical Nutrition ESPEN 2016, v.13: e-39-45.

Jo Edward, Kim JS, Ormsbee MJ, Prado C, Khamoui AV. The Physiological Basis For Weight Recidivism Following Severe Caloric Restrictive Diet Therapies: A Molecular Rationale For Exercise-And Nutrition-Based Treatment Optimization. Journal of Advanced Nutrition and Human Metabolism. 2016; 2:e1105. doi: 10.14800/janhm.1105 

Purcell S, Elliott SA, Kroenke CH, Sawyer MB, Prado CM. Impact of Body Weight and Body Composition on Ovarian Cancer Prognosis. Current Oncology Reports, 2016. 18(2): 1-11. 

Prado CM, Cushen S, Orsso C, Ryan A. Sarcopenia and Cachexia in the Era of Obesity: Clinical and Nutritional Impact. Proceeding of the Nutrition Society. 2016 May;75(2):188-98. 

Ryan AM, Power DG, Daly L, Cushen SJ, Bhuachalla EN, Prado CM. Cancer-associated malnutrition, cachexia and sarcopenia: The skeleton in the hospital closed 40 years later. Proceeding of the Nutrition Society. 2016 May;75(2):199-211.

Sawyer MB, Pituskin E, Sambasivarao D, Bies RR, Vos LJ, Prado CM, Kuzma M, Scarfe AG, Clemons M, Tonkin K, Au HJ, Koski S, Joy AA, Smylie M, King K, Carandand D, Damaraju VL, Hanson J, Cass CE, Mackey JR. A uridine glucuronosyltransferase 2B7 polymorphism predicts epirubicin clearance and outcomes in early stage breast cancer. Clinical Breast Cancer. 2016 Apr;16(2):139-144.e3 

Vieira ER, Mendy A, Prado CM, Gasana J, Albatineh A. Falls, physical limitations, confusion and memory problems in people with type II diabetes, undiagnosed diabetes and prediabetes, and the influence of vitamins A, D and E. In press: Journal of Diabetes and its Complications. 2015;v.9(8):1159–1164. 

Purcell S, Thornberry R, Elliott SA, Panton L, Ormsbee MJ, Vieira ER, Kim J-S, Prado CM. Body composition, strength, and dietary intake of patients with hip or knee osteoarthritis. Canadian Journal of Dietetic Practice and Research. 2016, 77(2): 98-102, 

Prado CM, Gonzalez MC, Heymsfield SB. Body composition and obesity paradox. Current Opinion in Clinical Nutrition and Metabolic Care. 2015. 18(6): 535-51. 

Heyland D, Stapleton R, Mourtzakis M, Hough T, Morris P, Deutz NE, Colantuoni E, Day A, Prado CM, Needham DM. Combining nutrition and exercise to optimize survival and recovery from critical illness: conceptual and methodological issues. Clin Nutrition. 2016 Oct;35(5):1196-206. 

Hall DK, Bemis T, Brychta R, Chen K, Courville A, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV, Prado CM, Preuschl E, Siervo M, Skarulis M, Yannai L. Is a Calorie a Calorie? Metabolic Fat Balance Following Selective Isocaloric Restriction of Dietary Carbohydrate vs. Fat in Obese Adults. Cell Metabolism. 2015 22(3): 427-436. 

Montano-Loza AJ, Angulo P. Meza-Junco J, Prado CM, Sawyer MB, Beaumont C, Esfandiari N, Ma M, Baracos VE. Sarcopenic obesity and myosteratosis are associated with higher mortality in patients with cirrhosis. Journal of Cachexia, Sarcopenia and Muscle. 2016 v.7(2):126-135.

Siervo M, Prado C*, Hooper L, Munro A, Collerton J, Davies K, Kingston A, Mathers JC, Kirkwood TB, Jagger C. Serum osmolarity and haematocrit do not modify the association between the impedance index (Ht(2)/Z) and total body water in the very old: The Newcastle 85+ Study. Archives of Gerontology and Geriatrics. 2015;60(1):227-32. *co-first author

Prado CM, Heymsfield S. Lean Tissue Imaging: A New Era for Nutritional Assessment and Intervention. Journal of Parenteral and Enteral Nutrition. 2014; 38(8):940-53.

Siervo M, Prado CM, Mire E, Wells JCK, Heymsfield S, Katzmarzyk P. Body composition indexes of capacity model: gender and BMI-specific reference curves. Public Health Nutrition. 2014;18(7):1245-54.

de Souza RGM, Gomes AC, Prado CMM, Mota JF. Métodos de análise da composição corporal em obesos. Revista de Nutrição. 2014; 27(5)”569-83. (Manuscript in Portuguese).

de van der Schueren M, Elia M, Gramlich L, Johnson MP, Lim SL, Philipson T, Prado CM. Clinical and economic outcomes of nutrition interventions across the continuum of care. Annals of the New York Academy of Sciences. 2014;1321:20-40.

Siervo M, Bunn D, Prado CM, Hooper L. Accuracy of prediction equations for serum osmolarity in frail older people with and without diabetes. American Journal of Clinical Nutrition. 2014;100(3):867-76.

Prado CM
, Siervo M, Mire E, Heymsfield SB, Stephan BC, Broyles S, Smith SR, Wells JC, Katzmarzyk PT. A population-based approach to define body-composition phenotypes. The American Journal of Clinical Nutrition. 2014 Jun;99(6):1369-77.

Fogelman DR, Holmes H, Mohammed K, Katz MH, Prado CM, Lieffers J, Garg N, Varadhachary GR, Shroff R, Overman MJ, Garrett C, Wolff RA, Javle M. Does IGFR1 inhibition result in increased muscle mass loss in patients undergoing treatment for pancreatic cancer? Journal of Cachexia, Sarcopenia and Muscle. 2014 Dec;5(4):307-13.

Ormsbee MJ, Prado CM, Ilich JZ, Purcell S, Siervo M, Folsom A, Panton L. Osteosarcopenic obesity: the role of bone, muscle, and fat on health. Journal of Cachexia, Sarcopenia and Muscle. 2014 Sep;5(3):183-92.  

Montano-Loza AJ, Meza-Junco J, Baracos VE, Prado CM, Ma M, Tandon P, Meeberg G, Beaumont C, Esfandiari N, Sawyer MB, Kneteman N. Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation. Liver Transplantation. 2014;20(6):640-8

Prado CM, Baracos VE, Xiao J, Birdsell L, Stuyckens K, Park YC, Parekh T, Sawyer MB. The association between body composition and toxicities from the combination of Doxil and trabectedin inpatients with advanced relapsed ovarian cancer. Applied Physiology, Nutrition, and Metabolism. 2014;39(6):693-8.   

Esfandiari N, Ghosh S, Prado CM, Martin L, Mazurak V, Baracos VE. Age, obesity, sarcopenia, proximity to death explain reduced mean muscle attenuation in patients with advanced cancer. Journal of Frailty and Aging. 2014;3(1):3-8.

Siervo M, Prado CM, Stephan BC, Lara J, Muscariello E, Nasti G, Colantuoni A. Association of the body adiposity index (BAI) with metabolic risk factors in young and older overweight and obese womenEating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. 2014;19(3):397-402.

Prado CM, Sawyer MB, Ghosh S, Lieffers JR, Esfandiari N, Antoun S, Baracos V. The central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential? American Journal of Clinical Nutrition. 2013;98(4):1012-9.

Prado CM. Body composition in chemotherapy: the promising role of CT scans. Current Opinion in Clinical Nutrition and Metabolic Care. 2013;16(5)525-33.

Prado CM, Maia YLM, Ormsbee M, Sawyer M. Baracos VE. Assessment of nutritional status in cancer – the relationship between body composition and pharmacokinetics. Anti-Cancer Agents in Medicinal Chemistry. 2013;13(8):1197-203.

Meza-Junco, Montano-Loza AJ,Baracos VE, Prado CM, Bain VG, Beaumont, C, Esfandiari N, Lieffers JR, Sawyer MB. Sarcopenia as a prognostic index of nutritional status in concurrent cirrhosis and hepatocellular carcinoma. Journal of Clinical Gastroenterology. 2013; 47(10):861-70. 

Prado CM, Lieffers JR, Bowthorpe L, Baracos VE, Mourtzakis M, McCargar LJ. Sarcopenia and Physical Function in Overweight Patients with Advanced CancerCanadian Journal of Dietetic Practice and Research. 2013;74(2):69-74.

Thoresen L, Frykholm G, Ludersen S, Ulveland H, Baracos V, Prado CM, Birdsell L, Falkmer U. Nutritional status, cachexia and survival in patients with advanced colorectal carcinoma. Different assessment criteria for nutritional status provide unequal results. Clinical Nutrition.2013;32(1):65-72.

Prado CM, Wells JCK, Smith S, Stephan BCM, Siervo M. Sarcopenic Obesity: A Critical Appraisal of the Current Evidence. Clinical Nutrition. 2012;31(5):583-601.

Siervo M, Nasti G, Stephan BCM, Papa A, Muscariello E, Wells JCK, Prado CM, Colantuoni A. Effects of intentional weight loss on physical and cognitive function in middle-aged and older obese subjects: a pilot study.  Journal of The American College of Nutrition. 2012;31(2):79-86.

Prado CM, Lieffers JR, Bergsten G, Mourtzakis M, Baracos V, McCargar LJ. Dietary patterns of patients with advanced lung or colorectal cancerCanadian Journal of Dietetic Practice and Research. 2012;73(4):e298-303.

Prado CM, Bekaii-Saab T, Doyle LA, Shrestha S, Ghosh S, Baracos VE, Sawyer MB. Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor - selemetunib in patients with cholangiocarcinoma. The British Journal of Cancer. 2012;106(10):1583-6.  

Montano-Loza AJ, Meza-Junco J, Prado CM, Lieffers JR, Baracos VE, Bain VG, Sawyer MB. Muscle wasting is associated with mortality in patients with cirrhosis. Clinical Gastroenterology and Hepatology. 2012;10(2):166-73. 

Stretch C, Eastman T, Mandal R, Eisner R, Wishart DS, Mourtzakis M, Prado CMM, Damaraju S, Ball RO, Greiner R, Baracos VE. Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach. The Journal of Nutrition. 2012;142(1):14-21.

Prado CMM, Antoun S, Sawyer MB, Baracos VE. Two faces of drug therapy in cancer: drug-related lean tissue loss and its adverse consequences to survival and toxicity. Current Opinion in Nutrition & Metabolic Care. 2011;14(3):250-4.

Prado CM, Lima IS, Baracos VE, Bies RR, McCargar LJ, Reiman T, Mackey JR, Kuzma M, Damaraju VL, Sawyer MB, An exploratory study of body composition as a determinant of epirubicin pharmacokinetics and toxicity. Cancer Chemotherapy and Pharmacology.  2011;67(1):93-101.

Prado CM, Mourtzakis M, Baracos VE, Reiman T, Sawyer MB, McCargar LJ. Overweight and obese patients with solid tumors may have sarcopenia, poor prognosis and early features of cachexia. International Journal of Body Composition. 2010;8(1):7-15.

Prado CM, Birdsell LA, Baracos VE. The emerging role of computerized tomography in assessing cancer cachexia. Current Opinion in Supportive and Palliative Care. 2009;3:269-275

Prado CM, Baracos VE, McCargar LJ, Reiman T, Mourtzakis M, Tonkin K, Mackey JR, Koski S, Pituskin E, Sawyer MB. Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clinical Cancer Research. 2009;15(8):2920-6.

Lieffers JR, Mourtzakis M, Hall KD, McCargar LJ, Prado CM, Baracos VE. A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. The American Journal of Clinical Nutrition. 2009;89(4):1173-9.

Mourtzakis M, Prado CM, Reiman T, McCargar LJ, and Baracos VE. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Applied Physiology, Nutrition and Metabolism. 2008;33(5):997-1006.

Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, and Baracos VE. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncology. 2008;9(7):629-35.

Prado CM, Baracos VE, McCargar LJ, Mourtzakis M, Mulder KE, Reiman T, Butts, CA, Scarfe AG, Sawyer MB. Body Composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity. Clinical Cancer Research. 2007;13(11):3264-8.

Naves MMV, Fernandes DC, Prado CM, Teixeira LSM. Food fortification with egg shell powder as a calcium source. Ciencia e Tecnologia de Alimentos. 2007; 27:99-103 (Manuscript in Portuguese).

Naves MMV, Prado CM, Fernandes DC, Serafini AB. Microbiological evaluation of egg shell powder and optimization of its preparation technique. Pesquisa Agropecuaria Tropical. 2007; 37:113-118 (Manuscript in Portuguese).

Machado DC, Maia CM, Carvalho ID, Silva NF, Andres MCPB, Serafini AB. Microbiological quality of organic vegetables produced in soil treated with different types of manure and mineral fertilizer. Brazilian Journal of Microbiology. 2006; 37:538-544.